standard and pegylated interferon therapy of hdv infection: a systematic review and meta-analysis

نویسندگان

seyed-moayed alavian baqiyatallah university of medical sciences, baqiyatallah research center for gastroenterology and liver disease, tehran, iran

seyed vahid tabatabaei university of muenster, st.-marien-hospital gmbh, klinik of gastroenterology, luenen, germany

bita behnava baqiyatallah university of medical sciences, baqiyatallah research center for gastroenterology and liver disease, tehran, iran

mario rizzetto division of gastroenterology, molinette, university of turin, turin, italy

چکیده

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: hepatitis d virus (hdv) infection is characterized by rapidly progressive liver disease with adverse prognosis in most patients. although interferon is the only approved anti-hdv therapy, evidence regarding the efficacy and safety of its various regimens is either old or scattered. materials and methods: we searched systematically medline, embase, scopus, the cochrane central register of controlled trials, and isi. the studies that evaluated treatment of chronic hdv infection with standard or pegylated interferon for at least 48 weeks were identified. our inclusion criteria were positive anti-hdv antibody for 6 months and positive hdv-pcr at the start of study. we performed a meta-analysis for proportions using the arcsine transformation in random effects model. sustained virological response (svr) rate (negative polymerase chain reaction (pcr) 6 months after cessation of therapy) was the end point of interest. results: data were abstracted from 14 studies containing 227 chronic hdv-infected patients who received standard or pegylated interferon alpha-2a or -2b. twenty-one and 30 patients of 71 and 156 who received standard or peginterferon, respectively, beyond 48 weeks achieved svr. pooled svr rates were 29% [95% confidence interval (ci) 19; 41] and 19% (95% ci 10; 29), respectively. the rates of treatment withdrawal were similar. conclusion: our systematic review indicates that the literature lacks sufficient evidence to establish precise recommendations for treatment of hdv infection. meta-analysis of these studies shows that standard dose of peginterferon is more effective than high dose of standard interferon as anti-hdv therapy.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Standard and pegylated interferon therapy of HDV infection: A systematic review and meta- analysis

BACKGROUND Hepatitis D virus (HDV) infection is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Although interferon is the only approved anti-HDV therapy, evidence regarding the efficacy and safety of its various regimens is either old or scattered. MATERIALS AND METHODS We searched systematically Medline, EMBASE, Scopus, the Cochrane Central Regist...

متن کامل

Cryptosporidium spp. infection in Iranian children and immunosuppressive patients: A systematic review and meta-analysis

Background: Cryptosporidiosis is an important cause of diarrhea in children and immunosuppressive patients. The current study was intended to evaluate the prevalence rate of Cryptosporidium infection and clarify the epidemiological characteristics of the infection in both children and immunosuppressive patients in Iran. Methods: Five English electronic databases including PubMed, Google Schola...

متن کامل

Prevalence of Nosocomial Infection in Iranian Hospitals: A Systematic Review and Meta- Analysis

Background and Objectives: A nosocomial infection (NI) is defined as an infection occurring in a patient after 48 hours of hospitalization or up to 72 hours after discharge from the hospital, which was not present or incubating at the time of admission. NIs increase hospital mortality, decrease patient satisfaction, reduce hospital productivity, and increase health system costs. This study was ...

متن کامل

Depression among Iranian nurses: A systematic review and meta-analysis

Background: Depression is one of the most commonly diagnosed mental disorders. Nurses and other hospital service providers are a group at high risk for developing depression. Thus, knowing the prevalence of depression among nurses can help the health care decision- makers to plan ad hoc prevention programs to control depression in this group. This study was conducted to quantitatively assess th...

متن کامل

Nutraceuticals in Hyperlipidemic Children: a Systematic Review and Meta-analysis

Background Dyslipidemia is a major risk for cardiovascular diseases. The aim of this study is to review the effects of nutraceuticals to modify lipid disorders in children. Materials and Methods The literature research was conducted in EMBASE, Medline, PubMed, Scopus, ISI Web of Science, and Cochrane library from 2002 until January 2015. The following keywords were used: dyslipidemia, hyperlipi...

متن کامل

‏‎a phonological contrastive analysis of kurdish and english‎‏

deposite the different criticisms on contrastive analysis it has been proved that the results of it(when processed)can be usuful in a tefl environment,specially at the level of phonology.this study is an attempt to compare and contrast the sound systems of kurdish and english for pedagogical aims. the consonants,vowels,stress and intonation of the twolanguages are described by the same model-ta...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
journal of research in medical sciences

جلد ۱۷، شماره ۱۰، صفحات ۰-۰

کلمات کلیدی
[ ' h e p a t i t i s d e l t a v i r u s l a r g e a n t i g e n ' , ' i n f e c t i o n ' , ' i n t e r f e r o n s r n / * s t y l e d e f i n i t i o n s * / r n t a b l e . m s o n o r m a l t a b l e r n t { m s o ' , ' s t y l e ' , ' n a m e ' , ' & ' , ' q u o t ' , ' t a b l e n o r m a l & ' , ' q u o t ' , ' m s o ' , ' t s t y l e ' , ' r o w b a n d ' , ' s i z e ' , 0 , ' m s o ' , ' t s t y l e ' , ' c o l b a n d ' , ' s i z e ' , 0 , ' m s o ' , ' s t y l e ' , ' n o s h o w ' , ' y e s ' , ' m s o ' , ' s t y l e ' , ' p r i o r i t y ' , 9 9 , ' m s o ' , ' s t y l e ' , ' q f o r m a t ' , ' y e s ' , ' m s o ' , ' s t y l e ' , ' p a r e n t ' , ' & ' , ' q u o t ' , ' & ' , ' q u o t ' , ' m s o ' , ' p a d d i n g ' , ' a l t ' , ' 0 i n 5 . 4 p t 0 i n 5 . 4 p t ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' t o p ' , ' 3 . 0 p t ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' r i g h t ' , ' . 7 p t ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' b o t t o m ' , ' 0 i n ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' l e f t ' , ' 0 i n ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' b o t t o m ' , ' . 0 0 0 1 p t ' , ' l i n e ' , ' h e i g h t ' , ' 1 2 . 5 p t ' , ' m s o ' , ' l i n e ' , ' h e i g h t ' , ' r u l e ' , ' e x a c t l y ' , ' m s o ' , ' p a g i n a t i o n ' , ' w i d o w ' , ' o r p h a n ' , ' f o n t ' , ' s i z e ' , ' 1 1 . 0 p t ' , ' f o n t ' , ' f a m i l y ' , ' & ' , ' q u o t ' , ' c a l i b r i & ' , ' q u o t ' , ' & ' , ' q u o t ' , ' s a n s ' , ' s e r i f & ' , ' q u o t ' , ' m s o ' , ' a s c i i ' , ' f o n t ' , ' f a m i l y ' , ' c a l i b r i ' , ' m s o ' , ' a s c i i ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' l a t i n ' , ' m s o ' , ' f a r e a s t ' , ' f o n t ' , ' f a m i l y ' , ' & ' , ' q u o t ' , ' t i m e s n e w r o m a n & ' , ' q u o t ' , ' m s o ' , ' f a r e a s t ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' f a r e a s t ' , ' m s o ' , ' h a n s i ' , ' f o n t ' , ' f a m i l y ' , ' c a l i b r i ' , ' m s o ' , ' h a n s i ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' l a t i n ' , ' m s o ' , ' b i d i ' , ' f o n t ' , ' f a m i l y ' , ' a r i a l ' , ' m s o ' , ' b i d i ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' b i d i ' , ' } ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023